Analytical Data
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Gene name
MUSK
- Application
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Alternative Names
MUSK；Muscle. skeletal receptor tyrosine-Protein kinase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15146
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Expression Region
24-495aa
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AA Sequence
LPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEEESEPEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLAFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDI
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Molecular Weight
54.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MUSK (Muscle-Specific Kinase) is a receptor tyrosine kinase that plays a crucial role in the formation and maintenance of neuromuscular junctions. Its function is vital for muscle development and the proper signaling between motor neurons and muscle fibers. Research into MUSK has gained momentum due to its potential implications in neuromuscular disorders, such as myasthenia gravis and congenital myasthenic syndromes, where impaired signaling at the neuromuscular junction leads to muscle weakness and fatigue. Understanding the structural and functional aspects of MUSK through recombinant protein studies allows researchers to elucidate the molecular mechanisms underlying neuromuscular transmission and identify therapeutic targets for these conditions. Additionally, the recombinant production of MUSK can enhance our understanding of its interactions with other proteins involved in synaptic signaling and may contribute to the development of innovative treatment strategies. As scientists explore the intricate pathways regulated by MUSK, the insights gained from these studies have the potential to inform not only basic neuroscience but also clinical approaches in treating neuromuscular diseases. Thus, the research on MUSK recombinant proteins is significant in uncovering new avenues for therapeutic intervention and improving the quality of life for individuals affected by neuromuscular disorders.
