Analytical Data
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基因名
SFXN5
- Application
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别名
SFXN5; Sideroflexin-5
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TD22
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氨基酸序列
MADTATTASAAAASAASASSDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLIQRFVPFPAVASANICNVVLMRYGELEEGIDVLDSDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL
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分子量
37.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SFXN5, a member of the sideroflexin family of proteins, has garnered attention in recent years due to its potential role in cellular iron metabolism and mitochondrial function. Research has shown that SFXN5 may be involved in the transport of iron and the regulation of iron homeostasis, which is crucial for maintaining cellular health and preventing oxidative stress. Dysregulation of iron metabolism is linked to various diseases, including neurodegenerative disorders and cancer, highlighting the importance of understanding SFXN5's function. Given its location in the mitochondria, SFXN5 is also thought to play a role in mitochondrial dynamics and bioenergetics. Studies involving the recombinant expression of SFXN5 can provide insights into its specific biochemical properties and interactions. Moreover, exploring the structure-function relationship of this protein through techniques such as X-ray crystallography and cryo-electron microscopy may uncover its mechanism of action and identify potential therapeutic targets. As research progresses, SFXN5 may emerge as a key player in the intricate balance of iron metabolism and mitochondrial health, paving the way for novel interventions in diseases associated with metabolic dysfunctions.
