Analytical Data
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Gene name
SFXN2
- Application
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Alternative Names
SFXN2; Sideroflexin-2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96NB2
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Expression Region
1-322 aa
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AA Sequence
MEADLSGFNIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTQVEQLLYAKKLYDSAFHPDTGEKMNVIGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMLTKKAPPLVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMILLPVIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEPYVYFNKGL
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Molecular Weight
62.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SFXN2, or Sideroflexin 2, is a protein that belongs to the sideroflexin family, which is primarily involved in mitochondrial iron homeostasis and respiration. Recent studies have highlighted the critical role of SFXN2 in various cellular processes, including mitochondrial function, iron metabolism, and even cellular signaling pathways. Dysregulation of iron homeostasis is linked to several diseases, including neurodegenerative disorders and cancer, making SFXN2 a potential target for therapeutic interventions. Research into SFXN2 involves the production of recombinant proteins to investigate their structure, function, and interaction with other cellular components. By utilizing techniques such as recombinant DNA technology and protein expression systems, scientists aim to produce SFXN2 in a controlled environment to study its biochemical properties and functional implications. Understanding the mechanisms by which SFXN2 influences iron metabolism and mitochondrial function could provide valuable insights into therapeutic strategies for diseases associated with iron dysregulation. This research is crucial for developing potential interventions that could mitigate the impact of iron-related disorders on human health.
