Analytical Data
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基因名
STAT6
- Application
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别名
STAT6；Signal transducer and activator of transcription 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42226
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表达区间
627-837aa
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氨基酸序列
MSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMA PDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQM PPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQ PVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQ PSHYGQSGISMSLEHHHHHH
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分子量
24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAT6 (Signal Transducer and Activator of Transcription 6) is a critical transcription factor primarily involved in regulating immune responses, particularly in T helper 2 (Th2) cell differentiation and allergic reactions. Its role in mediating signals from cytokines such as IL-4 and IL-13 has made it a key focus in immunology research, especially regarding asthma and other allergic diseases. Given its central role in modulating gene expression in response to these cytokines, understanding the functions and interactions of STAT6 is crucial for developing targeted therapies. The study of recombinant STAT6 proteins allows researchers to investigate its structural and functional properties in detail, facilitating insights into how specific mutations and variations can affect its activity. Furthermore, recombinant STAT6 can be utilized in various assays to identify potential inhibitors or modulators, leading to novel therapeutic agents for allergic conditions and other diseases where STAT6 is implicated. As research progresses, the exploration of STAT6 as a therapeutic target continues to hold promise in the management of Th2-mediated pathologies, highlighting the necessity of detailed studies focusing on its recombinant forms to elucidate their potential roles in both basic and applied biomedical research.
