Analytical Data
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基因名
CLDN10
- Application
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别名
CLDN10; Claudin-10; Oligodendrocyte-specific protein-like; OSP-like
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78369
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表达区间
1-228aa
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氨基酸序列
MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGVSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV
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分子量
50.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLDN10, or Claudin-10, is a member of the claudin family of proteins that play a crucial role in the formation of tight junctions between epithelial cells. These tight junctions are vital for maintaining the integrity of cell barriers, regulating paracellular permeability, and ensuring proper tissue homeostasis. Recent studies have indicated that CLDN10 may have significant implications in various pathological conditions, including cancer, where altered tight junction functions contribute to increased metastatic potential. Additionally, CLDN10 has been associated with kidney and gastrointestinal disorders, highlighting its potential as a biomarker for disease progression or prognosis. The increasing interest in understanding the structural and functional properties of CLDN10 has led to the development of recombinant CLDN10 proteins for further research. By producing and characterizing these recombinant proteins, scientists aim to investigate the mechanisms underlying CLDN10's role in cell adhesion, signaling pathways, and its interactions with other cellular components. This research is essential to comprehend how aberrations in CLDN10 expression or function can contribute to disease and to explore its potential as a therapeutic target or diagnostic marker, paving the way for innovative treatment strategies in related diseases.
