Cat: PA2000-6722

Recombinant Human CLDN10 Protein,GST

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Analytical Data

  • Gene name

    CLDN10

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CLDN10; Claudin-10; Oligodendrocyte-specific protein-like; OSP-like

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P78369

  • Expression Region

    1-228aa

  • AA Sequence

    MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGVSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV

  • Molecular Weight

    50.9 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

CLDN10, or Claudin-10, is a member of the claudin family of proteins that play a crucial role in the formation of tight junctions between epithelial cells. These tight junctions are vital for maintaining the integrity of cell barriers, regulating paracellular permeability, and ensuring proper tissue homeostasis. Recent studies have indicated that CLDN10 may have significant implications in various pathological conditions, including cancer, where altered tight junction functions contribute to increased metastatic potential. Additionally, CLDN10 has been associated with kidney and gastrointestinal disorders, highlighting its potential as a biomarker for disease progression or prognosis. The increasing interest in understanding the structural and functional properties of CLDN10 has led to the development of recombinant CLDN10 proteins for further research. By producing and characterizing these recombinant proteins, scientists aim to investigate the mechanisms underlying CLDN10's role in cell adhesion, signaling pathways, and its interactions with other cellular components. This research is essential to comprehend how aberrations in CLDN10 expression or function can contribute to disease and to explore its potential as a therapeutic target or diagnostic marker, paving the way for innovative treatment strategies in related diseases.

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