Analytical Data
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基因名
ERBB4
- Application
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别名
ERBB4；HER4；Receptor tyrosine-Protein kinase erbB-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15303-1
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表达区间
26-651aa
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氨基酸序列
QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLS FLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRK DGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNL TLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPY VSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQL EHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKP CTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHG DPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGG RVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWT TLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRR FSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPD NCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGC NGPTSHDCIYYPWTGHSTLPQHARTP
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分子量
96 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERBB4, a member of the epidermal growth factor receptor (EGFR) family, plays a pivotal role in various cellular processes including proliferation, differentiation, and survival. Its unique receptor isoforms, generated through alternative splicing, contribute to diverse signaling pathways that are crucial in both normal physiological functions and pathological conditions, such as cancer. Recent studies have highlighted ERBB4's importance not only in tumor biology but also in neurodevelopmental processes, particularly in the brain where it influences neuronal communication and synaptic plasticity. The dysregulation of ERBB4 signaling has been implicated in several disorders, including schizophrenia and various forms of cancer, making it a potential therapeutic target. As such, the development of ERBB4 recombinant proteins is gaining attention, as these proteins can be utilized to elucidate the receptor's function, identify interaction partners, and screen for small molecule inhibitors. By harnessing recombinant DNA technology, researchers can produce these proteins in sufficient quantities for detailed biochemical and biophysical analysis. Understanding the structure-function relationship of ERBB4 through its recombinant forms is crucial for the design of novel therapeutic strategies aimed at modulating its activity in disease contexts. As research progresses, ERBB4 remains a significant focus in the field of molecular biology and cancer therapeutics, paving the way for innovative interventions to combat associated diseases.
