Analytical Data
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Gene name
MYBPC2
- Application
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Alternative Names
MYBPC2；MYBPCF；Myosin-binding Protein C. fast-type
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14324
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Expression Region
739-1141aa
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AA Sequence
EPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAGRSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSRVHVRTSDFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKDDGNSEIMGYFVQKADKKTMEWFNVYERNRHTSCTVSDLIVGNEYYFRVYTENICGLSDSPGVSKNTARILKTGITFKPFEYKEHDFRMAPKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNELGEALAECKLEVRVPQ
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Molecular Weight
47.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MYBPC2 gene encodes cardiac muscle protein, a crucial component of the sarcomere in cardiac tissue, playing a vital role in regulating cardiac contraction and relaxation. Mutations in MYBPC2 are linked to familial hypertrophic cardiomyopathy (HCM), a condition characterized by abnormal heart muscle thickening, which can lead to serious health issues, including heart failure and sudden cardiac death. Due to its significant role in cardiac function and disease, the production and study of recombinant MYBPC2 protein have garnered considerable interest in the field of molecular biology and cardiology. Research on MYBPC2 recombinant protein aims to elucidate the structural and functional properties of the protein, understand the molecular mechanisms underlying HCM, and promote the development of potential therapeutic strategies. By investigating the interactions of MYBPC2 with other sarcomeric proteins, scientists hope to uncover insights that could lead to innovative treatments or diagnostic tools for heart-related disorders. Recombinant MYBPC2 also serves as a valuable model for screening small molecules or peptides that may restore normal function to the mutated proteins, thereby offering a path toward targeted therapies for patients affected by MYBPC2-related diseases. Overall, the study of MYBPC2 recombinant protein holds promise for advancing our knowledge of cardiac biology and improving clinical outcomes in patients with genetic cardiomyopathies.
