Analytical Data
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基因名
MYBPC2
- Application
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别名
MYBPC2；MYBPCF；Myosin-binding Protein C. fast-type
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14324
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表达区间
739-1141aa
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氨基酸序列
EPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAGRSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSRVHVRTSDFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKDDGNSEIMGYFVQKADKKTMEWFNVYERNRHTSCTVSDLIVGNEYYFRVYTENICGLSDSPGVSKNTARILKTGITFKPFEYKEHDFRMAPKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNELGEALAECKLEVRVPQ
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分子量
47.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MYBPC2 gene encodes cardiac muscle protein, a crucial component of the sarcomere in cardiac tissue, playing a vital role in regulating cardiac contraction and relaxation. Mutations in MYBPC2 are linked to familial hypertrophic cardiomyopathy (HCM), a condition characterized by abnormal heart muscle thickening, which can lead to serious health issues, including heart failure and sudden cardiac death. Due to its significant role in cardiac function and disease, the production and study of recombinant MYBPC2 protein have garnered considerable interest in the field of molecular biology and cardiology. Research on MYBPC2 recombinant protein aims to elucidate the structural and functional properties of the protein, understand the molecular mechanisms underlying HCM, and promote the development of potential therapeutic strategies. By investigating the interactions of MYBPC2 with other sarcomeric proteins, scientists hope to uncover insights that could lead to innovative treatments or diagnostic tools for heart-related disorders. Recombinant MYBPC2 also serves as a valuable model for screening small molecules or peptides that may restore normal function to the mutated proteins, thereby offering a path toward targeted therapies for patients affected by MYBPC2-related diseases. Overall, the study of MYBPC2 recombinant protein holds promise for advancing our knowledge of cardiac biology and improving clinical outcomes in patients with genetic cardiomyopathies.
