Analytical Data
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基因名
PIGR
- Application
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别名
PIGR；Polymeric immunoglobulin receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01833
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表达区间
19-638aa
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氨基酸序列
KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLI SSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRG LSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQ IGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQY LCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAK FLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKE DAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGGSVA VLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEE PGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPG NVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFV NCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAA GSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPRLFAEEKAVADTRDQA DGSRASVDSGSSEEQGGSSR
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分子量
69 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIGR (Polymeric Immunoglobulin Receptor) is a critical protein involved in the transport of dimeric immunoglobulin A (dIgA) and secretory immunoglobulin A (sIgA) across epithelial cells, playing an essential role in mucosal immunity. The study of PIGR has gained significant attention due to its potential implications in various physiological and pathological conditions, including autoimmune diseases, infections, and cancer. Research has shown that PIGR is instrumental in maintaining immune homeostasis at mucosal surfaces by facilitating the secretion of immunoglobulins that protect against pathogens. Additionally, altered expression of PIGR has been linked to inflammatory responses and may serve as a marker for disease progression in conditions such as inflammatory bowel disease (IBD) and respiratory infections. The recombinant expression of PIGR allows for in-depth studies of its structure, function, and interactions with other molecules in the immune system. Such research not only enhances our understanding of mucosal immunity but also opens up avenues for developing therapeutic strategies targeting PIGR pathways, potentially leading to novel treatment options for diseases where mucosal immunity is compromised. As a result, the investigation into PIGR and its recombinant protein forms is poised to become a crucial area of study, shedding light on new immunological mechanisms and therapeutic interventions.
