Analytical Data
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Gene name
SCNM1
- Application
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Alternative Names
SCNM1; Sodium channel modifier 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BWG6
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Expression Region
1-230 aa
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AA Sequence
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR PVLDTLAMLT AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET KAEAPLLTQT RLITQSALHR APHYNSCCRR KYRPEAPGPS VSLSPMPPSE VKLQSGKISR EPEPAAGPQA EESATVSAPA PMSPTRRRAL DHYLTLRSSG WIPDGRGRWV KDENVEFDSD EEEPPDLPLD
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Molecular Weight
25.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCNM1, or Suppressor of Chromosomal Instability 1, is a protein that has garnered significant interest due to its potential role in maintaining genomic stability and its implications in cancer biology. Characterized by a unique structure and functional motifs, SCNM1 is involved in various cellular processes, including regulation of gene expression and modulation of chromosomal stability during cell division. Recent studies have shown that anomalies in SCNM1 expression or function can lead to increased chromosomal instability, which is a hallmark of many cancers. Understanding the mechanistic pathways involving SCNM1 can reveal crucial insights into tumorigenesis and may offer new therapeutic targets. Researchers are focusing on the recombinant expression of SCNM1 to explore its biochemical properties, interactions with other proteins, and its effects on cellular functions. By employing advanced techniques such as X-ray crystallography and nuclear magnetic resonance (NMR), scientists aim to elucidate the three-dimensional structure of SCNM1 and understand how specific mutations may alter its function. This research not only enhances our knowledge of SCNM1's biological role but also opens avenues for the development of targeted therapies that could mitigate tumorigenic processes influenced by this protein. The study of recombinant SCNM1 thus stands at the intersection of molecular biology and clinical application, highlighting its significance in both fundamental research and potential therapeutic advancements.
