Analytical Data
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基因名
CHRND
- Application
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别名
CHRND. ACHRD
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q07001
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表达区间
24-130aa
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氨基酸序列
EEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCN
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分子量
37.51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHRND (Cholinergic Receptor Nicotinic Delta Subunit) is a significant protein that plays a crucial role in the formation and function of nicotinic acetylcholine receptors (nAChRs), which are vital for neurotransmission in the nervous system. Research on CHRND has gained importance due to its involvement in neuromuscular junctions and its potential links to various neurological disorders. Alterations in nAChR function, including the delta subunit, have been implicated in conditions such as myasthenia gravis, Alzheimer's disease, and schizophrenia. Studying CHRND at the molecular level can provide insights into receptor assembly, signaling pathways, and potential therapeutic targets. Recombinant CHRND protein is therefore essential for in vitro studies that examine its structural and functional characteristics, as well as its interactions with other subunits and ligands. Such investigations can aid in understanding receptor pharmacology and contribute to the development of drugs that selectively target nAChRs for therapeutic purposes. Moreover, the expression of recombinant CHRND allows researchers to explore the effects of mutations and investigate the mechanisms underlying receptor-related pathologies, paving the way for innovative treatment strategies for neurodegenerative diseases and other related disorders.
