Analytical Data
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基因名
SCNN1D
- Application
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别名
Amiloride sensitive sodium channel subunit delta; Amiloride-sensitive sodium channel subunit delta; Delta ENaC; Delta NaCH; Delta-ENaC; Delta-NaCH; DNACH; ENaC Delta; ENaCD; ENaCdelta; Epithelial Na(+) channel subunit delta; MGC149710; MGC149711; Nonvoltage gated sodium channel 1 subunit delta; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; SCNN1D; SCNND_HUMAN; Sodium channel. nonvoltage gated 1. delta
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51172
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表达区间
1-638 aa
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氨基酸序列
MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
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分子量
96.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCNN1D, also known as the epithelial sodium channel (ENaC) delta subunit, has emerged as a significant focus in physiological and pathophysiological research due to its critical role in ion transport and fluid balance in various tissues, particularly in the kidneys and lungs. This protein is part of the ENaC family, which regulates sodium reabsorption and, consequently, blood pressure homeostasis. Mutations or dysregulations in SCNN1D can lead to severe clinical conditions such as pseudohypoaldosteronism type 1, a disorder characterized by salt-wasting and hyperkalemia. Given its physiological importance, understanding the structure and function of SCNN1D is essential for developing targeted therapies. Researchers have leveraged techniques such as recombinant protein expression to investigate the functional properties of SCNN1D, enhancing our understanding of its interactions with other channel subunits and regulatory proteins. Characterizing SCNN1D at a molecular level will not only elucidate its role in normal physiology but also provide insights into the mechanisms underlying associated diseases, paving the way for potential therapeutic interventions.
