Analytical Data
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基因名
MBTPS1
- Application
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别名
MBTPS1；KIAA0091；S1P；SKI1；Membrane-bound transcription factor site-1 protease
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14703
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表达区间
187-400aa
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氨基酸序列
RAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRG
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分子量
27.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MBTPS1 (Membrane-Bound Transcription Factor Peptidase Site 1) is a crucial component of the regulated intramembrane proteolysis (RIP) pathway, which plays a significant role in the cellular response to stress and homeostasis. This enzyme is responsible for cleaving substrates such as sterol regulatory element-binding proteins (SREBPs), which are essential in the regulation of lipid metabolism and cellular cholesterol homeostasis. Recent studies have highlighted the importance of MBTPS1 in various diseases, including metabolic disorders, neurodegenerative diseases, and certain cancers, as it mediates the activation of signaling pathways involved in cell survival and apoptosis. Furthermore, dysregulation of MBTPS1 is linked to impaired lipid metabolism and increased susceptibility to lipid-related diseases. Researchers are increasingly focused on the structure, function, and regulatory mechanisms of MBTPS1, aiming to develop targeted therapies that can modulate its activity. By understanding the molecular intricacies of MBTPS1, scientists hope to unveil novel strategies for treating conditions associated with lipid dysregulation and other related pathologies, making it a pivotal target in biomedical research.
