Analytical Data
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基因名
SCN1B
- Application
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别名
Sodium channel regulatory subunit beta-1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q07699
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表达区间
1-218 aa
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氨基酸序列
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
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分子量
49.61 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCN1B, encoding the sodium channel beta-1 subunit, plays a crucial role in the modulation of voltage-gated sodium channels, impacting neuronal excitability and action potential propagation. Mutations or dysregulation of SCN1B are associated with various neurological disorders, particularly genetic epilepsy syndromes such as Dravet syndrome. Research into SCN1B recombinant proteins is essential for understanding the functional consequences of specific mutations, as well as their interactions with alpha subunits of sodium channels and other proteins. By using recombinant DNA technology, scientists can produce and purify SCN1B proteins to study their biochemical properties and physiological roles in cellular models. This analysis provides insights into the mechanisms underlying sodium channel dysfunctions and their contribution to epilepsy pathophysiology, paving the way for potential therapeutic strategies targeting sodium channel activity. Moreover, examining SCN1B in the context of its interactions with different channel subtypes and other auxiliary proteins maximizes our understanding of neuronal signaling and its implications in disease states. This research holds promise for identifying novel biomarkers and developing targeted interventions for patients suffering from sodium channel-related disorders.
