Analytical Data
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Gene name
hmt2
- Application
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Alternative Names
hmt2；HMT2；HRMT1L2；IR1B4；Protein arginine N-methyltransferase 1
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Species
E.coli
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94284
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Expression Region
25-459aa
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AA Sequence
ASTHHKVLVVGGGSAGISVAHQIYNKFSKYRFANDQGKDTSLKPGEIGIVDGAKYHYYQPGWTLTGAGLSSVAKTRRELASLVPADKFKLHPEFVKSLHPRENKIVTQSGQEISYDYLVMAAGIYTDFGRIKGLTEALDDPNTPVVTIYSEKYADAVYPWIEKTKSGNAIFTQPSGVLKCAGAPQKIMWMAEDYWRRHKVRSNIDVSFYTGMPTLFSVKRYSDALLRQNEQLHRNVKINYKDELVEVKGSERKAVFKNLNDGSLFERPFDLLHAVPSMRSHEFIAKSDLADKSGFVAVDQSTTQSTKFPNVFAIGDCSGLPTSKTYAAITAQAPVMVHNLWSFVNGKNLTASYNGYTSCPLLTGYGKLILAEFLYKQEPKESFGRFSRFLDQTVPRRMFYHLKKDFFPFVYWNFAVRNGKWYGSRGLIPPHFPVN
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Molecular Weight
51.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HMT2, or Histone Methyltransferase 2, plays a crucial role in the regulation of gene expression through histone methylation, a fundamental epigenetic modification. This enzyme is responsible for adding methyl groups to specific lysine residues on histone tails, influencing chromatin structure and function. Aberrant expression or activity of HMT2 has been implicated in various human diseases, including cancers, where it can alter gene expression patterns that promote uncontrolled cell growth. Thus, understanding the mechanisms governing HMT2's function is vital for elucidating its role in normal cellular processes and disease states. Recent advances in recombinant protein technology have facilitated the production and purification of HMT2, enabling researchers to study its enzymatic activity, substrate specificity, and interaction with other epigenetic regulators. This research not only provides insights into the fundamental aspects of epigenetic regulation but also opens up potential therapeutic avenues for targeting HMT2 in disease contexts. As such, HMT2 remains a focal point in epigenetics research, with ongoing studies aimed at delineating its precise biological functions and potential as a drug target.
