Analytical Data
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Gene name
IL17RD
- Application
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Alternative Names
IL17RD；IL17RLM；SEF；Interleukin-17 receptor D
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFM7
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Expression Region
1-739aa
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AA Sequence
MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYFVKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYKLKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDTNTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESSESSTYTAALPRERLRPRPKVFLCYSSKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNYKHKGGGRGSGKGELFLVAVSAIAEKLRQAKQSSSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFVPFHPPPLRYREPVLEKFDSGLVLNDVMCKPGPESDFCLKVEAAVLGATGPADSQHESQHGGLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPRDSGIYDSSVPSSELSLPLMEGLSTDQTETSSLTESVSSSSGLGEEEPPALPSKLLSSGSCKADLGCRSYTDELHAVAPL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IL17RD (Interleukin 17 receptor D) is a member of the IL-17 receptor family that plays a critical role in the immune response and inflammation. Its involvement in various inflammatory diseases, autoimmune disorders, and tumors has garnered significant research interest. The protein acts as a co-receptor for IL-17 cytokines, which are crucial in mediating inflammation and are linked to conditions such as rheumatoid arthritis, psoriasis, and multiple sclerosis. Recent studies indicate that IL17RD may also participate in mediating crosstalk between different signaling pathways, including those involving the NF-κB and MAPK pathways, which are pivotal in cellular responses to stress and cytokine signaling. The understanding of IL17RD's structure and function is essential for developing targeted therapies aimed at modulating its activity in disease contexts. Furthermore, recombinant forms of IL17RD are being explored for their potential therapeutic applications and as tools for elucidating the underlying mechanisms of IL-17 signaling. The ongoing investigation into IL17RD is poised to provide insights into its role in health and disease, indicating that it might serve as a valuable biomarker or therapeutic target in treating various inflammatory conditions. These advancements underscore the importance of continuing research on IL17RD to fully understand its biological significance and therapeutic potential.
