Analytical Data
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Gene name
CDK10
- Application
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Alternative Names
CDC2 related Protein kinase; Cdk10; CDK10_HUMAN; Cell division Protein kinase 10; Cyclin dependent kinase 10; Cyclin dependent kinase related Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14735
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Expression Region
1-313aa
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AA Sequence
MGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
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Molecular Weight
64 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDK10 (Cyclin-Dependent Kinase 10) is a member of the cyclin-dependent kinase family, which plays a crucial role in regulating various cellular processes, including cell cycle progression and transcription. The research on CDK10 has gained traction due to its involvement in cancer biology and its potential as a therapeutic target. Preliminary studies have suggested that CDK10 functions in promoting the phosphorylation of specific substrates, thereby influencing gene expression and cell proliferation. Additionally, deregulation of CDK10 has been linked to various malignancies, including breast cancer and colorectal cancer, suggesting that it may act as a tumor suppressor in some contexts. Furthermore, CDK10's role in the regulation of alternative splicing has highlighted its importance in maintaining cellular homeostasis. Gaining insights into the precise mechanisms governing CDK10 activity and its interactions with other cellular pathways is essential for developing innovative strategies for cancer therapy. Overall, the characterization of CDK10's functional roles and the exploration of its potential as a biomarker or therapeutic target promise to advance our understanding of tumor biology and enhance treatment options for patients.
