Analytical Data
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Gene name
CBG
- Application
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Alternative Names
CBG；CBG；Corticosteroid-binding globulin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08185
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Expression Region
23-405aa
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AA Sequence
MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISM ALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTS LEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINS YVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFY VDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGK MNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIA DLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTS KPIILRFNQPFIIMIFDHFTWSSLFLARVMNPVLDHHHHHH
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CBG (Corticosteroid-Binding Globulin) is a crucial plasma protein that plays a significant role in the transport and regulation of steroid hormones, particularly cortisol and cortisone. The importance of CBG in the endocrine system has prompted extensive research into its structure, function, and potential applications in medical science. CBG not only serves as a carrier for glucocorticoids but also modulates their bioavailability, thereby influencing various physiological responses and stress reactions. Dysregulation of CBG levels has been associated with various health conditions, including adrenal insufficiency, inflammatory diseases, and metabolic disorders, making it a target for therapeutic interventions. Recent advancements in recombinant protein technologies have enabled the production of CBG in vitro, facilitating detailed studies of its properties and interactions with steroids. These recombinant CBG proteins can be utilized in both research and clinical settings to investigate the implications of CBG in health and disease, expanding our understanding of steroid hormone dynamics and potentially leading to novel treatments for related disorders. The ongoing exploration of CBG and its functionalities continues to be a promising avenue for advancing endocrine research and therapeutic strategies.
