Analytical Data
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基因名
CBG
- Application
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别名
CBG；CBG；Corticosteroid-binding globulin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08185
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表达区间
23-405aa
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氨基酸序列
MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISM ALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTS LEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINS YVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFY VDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGK MNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIA DLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTS KPIILRFNQPFIIMIFDHFTWSSLFLARVMNPVLDHHHHHH
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分子量
44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBG (Corticosteroid-Binding Globulin) is a crucial plasma protein that plays a significant role in the transport and regulation of steroid hormones, particularly cortisol and cortisone. The importance of CBG in the endocrine system has prompted extensive research into its structure, function, and potential applications in medical science. CBG not only serves as a carrier for glucocorticoids but also modulates their bioavailability, thereby influencing various physiological responses and stress reactions. Dysregulation of CBG levels has been associated with various health conditions, including adrenal insufficiency, inflammatory diseases, and metabolic disorders, making it a target for therapeutic interventions. Recent advancements in recombinant protein technologies have enabled the production of CBG in vitro, facilitating detailed studies of its properties and interactions with steroids. These recombinant CBG proteins can be utilized in both research and clinical settings to investigate the implications of CBG in health and disease, expanding our understanding of steroid hormone dynamics and potentially leading to novel treatments for related disorders. The ongoing exploration of CBG and its functionalities continues to be a promising avenue for advancing endocrine research and therapeutic strategies.
