Analytical Data
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基因名
ROBO3
- Application
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别名
Roundabout-like protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96MS0
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表达区间
64-531 aa
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氨基酸序列
PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT
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分子量
57.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ROBO3 (Roundabout guidance receptor 3) is a crucial member of the Roundabout family of axon guidance receptors, which play a vital role in neural development and pathfinding during embryogenesis. The research surrounding ROBO3 has gained momentum due to its involvement in various neural processes and its implications in several neurological disorders. ROBO3 is primarily known for its role in midline crossing of axons in the developing nervous system, where it interacts with its ligands to facilitate the correct wiring of neural circuits. Mutations or dysregulation of ROBO3 have been linked to conditions such as schizophrenia, autism spectrum disorders, and congenital malformations. Studies have shown that ROBO3 is involved in the modulation of neuronal connectivity and plasticity, making it a potential target for therapeutic interventions. Recent advances in recombinant protein techniques have enabled researchers to produce ROBO3 in vitro, providing a platform for detailed functional analysis and the exploration of its signaling pathways. Understanding the structural and functional properties of recombinant ROBO3 protein can pave the way for elucidating its roles in neurodevelopment and its potential as a biomarker or therapeutic target in neurodevelopmental disorders. Consequently, the study of ROBO3 and its recombinant forms is critical for advancing our knowledge of neural development and for developing innovative strategies to treat related neurological diseases.
