Analytical Data
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基因名
PNLIP
- Application
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别名
PNLIP；Pancreatic triacylglycerol lipase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16233
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表达区间
17-465aa
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氨基酸序列
KEVC YERLGCFSDD SPWSGITERP LHILPWSPKD VNTRFLLYTN ENPNNFQEVA ADSSSISGSN FKTNRKTRFI IHGFIDKGEE NWLANVCKNL FKVESVNCIC VDWKGGSRTG YTQASQNIRI VGAEVAYFVE FLQSAFGYSP SNVHVIGHSL GAHAAGEAGR RTNGTIGRIT GLDPAEPCFQ GTPELVRLDP SDAKFVDVIH TDGAPIVPNL GFGMSQVVGH LDFFPNGGVE MPGCKKNILS QIVDIDGIWE GTRDFAACNH LRSYKYYTDS IVNPDGFAGF PCASYNVFTA NKCFPCPSGG CPQMGHYADR YPGKTNDVGQ KFYLDTGDAS NFARWRYKVS VTLSGKKVTG HILVSLFGNK GNSKQYEIFK GTLKPDSTHS NEFDSDVDVG DLQMVKFIWY NNVINPTLPR VGASKIIVET NVGKQFNFCS PETVREEVLL TLTPC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PNLIP (Pancreatic Lipase-Related Protein 1) is a member of the lipase family, which plays a critical role in lipid metabolism and digestion. Its enzymatic activity is essential for the hydrolysis of triglycerides into free fatty acids and glycerol, thereby facilitating fat absorption in the intestine. Research on PNLIP has gained momentum due to its implications in various metabolic disorders, obesity, and cardiovascular diseases. Additionally, PNLIP is of interest in the context of genetic studies, as polymorphisms in the PNLIP gene may influence individual susceptibility to obesity and metabolic diseases. Investigating the structure and function of PNLIP is paramount for understanding its biological roles and potential therapeutic applications. Moreover, recombinant protein technology allows for the production of PNLIP in controlled environments, enabling detailed studies of its enzymatic properties, binding mechanisms, and interactions with inhibitors. This research is not only crucial for advancing our understanding of lipid metabolism but also holds promise for the development of novel strategies to manage metabolic disorders through targeted therapies or dietary interventions. Overall, PNLIP serves as a significant model for exploring the complexities of lipid digestion and metabolism, paving the way for innovative approaches to combat related health issues.
