Analytical Data
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Gene name
RNUXA
- Application
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Alternative Names
FLJ13193; PHAX; PHAX_HUMAN; Phosphorylated adapter RNA export protein; Phosphorylated adaptor for RNA export; RNA U small nuclear RNA export adapter protein; RNA U; small nuclear RNA export adapter (phosphorylation regulated); RNUXA
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H814
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Expression Region
2-394 aa
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AA Sequence
ALEVGDMED GQLSDSDSDM TVAPSDRPLQ LPKVLGGDSA MRAFQNTATA CAPVSHYRAV ESVDSSEESF SDSDDDSCLW KRKRQKCFNP PPKPEPFQFG QSSQKPPVAG GKKINNIWGA VLQEQNQDAV ATELGILGME GTIDRSRQSE TYNYLLAKKL RKESQEHTKD LDKELDEYMH GGKKMGSKEE ENGQGHLKRK RPVKDRLGNR PEMNYKGRYE ITAEDSQEKV ADEISFRLQE PKKDLIARVV RIIGNKKAIE LLMETAEVEQ NGGLFIMNGS RRRTPGGVFL NLLKNTPSIS EEQIKDIFYI ENQKEYENKK AARKRRTQVL GKKMKQAIKS LNFQEDDDTS RETFASDTNE ALASLDESQE GHAEAKLEAE EAIEVDHSHD LDIF
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Molecular Weight
44.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNUXA is a protein that plays a crucial role in the regulation of RNA processing and metabolism. As an RNA-binding protein, RNUXA is primarily involved in the biogenesis and maturation of small nuclear RNAs (snRNAs) and other non-coding RNAs, which are essential components of the spliceosome and play a key role in pre-mRNA splicing. Research into RNUXA has gained momentum due to its implications in various cellular processes and diseases. Studies have shown that aberrations in RNA metabolism can lead to several disorders, including developmental defects and cancer. Furthermore, understanding the structure-function relationship of RNUXA could provide insights into its role in RNA-related pathways and its potential as a therapeutic target. The recombinant production of RNUXA facilitates detailed biochemical characterization and structural analyses, which are necessary for elucidating its mechanisms of action and interactions with other RNA-binding proteins and cellular factors. This research context highlights the significance of RNUXA in molecular biology and its potential impact on the development of novel therapeutic strategies targeting RNA processing pathways.
