Analytical Data
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基因名
CCNC
- Application
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别名
ccnc; CCNC_HUMAN; CycC ; Cyclin C; Cyclin-C; hSRB11; OTTHUMP00000016897; SRB11 homolog
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24863
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表达区间
1-283aa
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氨基酸序列
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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分子量
56.87 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCNC (Cyclin C) is a crucial component of the cell cycle regulatory system, primarily known for its role in the regulation of transcription and cellular proliferation. It binds with cyclin-dependent kinases (CDKs) to form complexes that are essential for the progression through specific phases of the cell cycle. Dysregulation of CCNC has been implicated in various cancers, making it a significant focus in cancer research. Recent studies have indicated that CCNC also plays a role in maintaining cellular homeostasis and may influence apoptosis and DNA damage response pathways. The recombinant expression of CCNC protein allows for the detailed study of its structure, function, and interactions within the cell, facilitating the understanding of its mechanistic roles in both normal cell cycle progression and the pathogenesis of cancer. Investigating the properties and dynamics of CCNC in vitro provides vital insights that can contribute to the development of targeted therapeutic strategies aimed at hindering cancer cell proliferation. Additionally, exploring the potential post-translational modifications of the CCNC protein can unravel its multifaceted roles in cellular signaling and metastasis. As such, CCNC stands at the intersection of fundamental biology and clinical application, representing a promising avenue for further research aimed at novel cancer treatment modalities.
