Analytical Data
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基因名
RNUT1
- Application
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别名
0610031A09Rik; KPNBL; MGC134006; MGC95000; RNA U transporter 1; RNA. U transporter 1; RNUT 1; RNUT1; SNUPN; Snupn1; Snurportin 1; Snurportin-1; Snurportin1; SPN1; SPN1_HUMAN; wu:fc41a03; zgc:77819
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95149
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表达区间
1-360 aa
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氨基酸序列
MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN
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分子量
41.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNUT1, or Regulator of Nonsense Transcripts 1, is a significant component of the nonsense-mediated mRNA decay (NMD) pathway, which plays a crucial role in protein synthesis by degrading faulty mRNAs that contain premature stop codons. This mechanism is essential for maintaining cellular homeostasis and preventing the accumulation of potentially harmful truncated proteins. Abnormalities in NMD pathways have been linked to various diseases, including cancer and genetic disorders, making RNUT1 an attractive target for therapeutic intervention. Recent studies have highlighted the importance of RNUT1 in regulating gene expression and its interactions with other cellular factors, which are vital for the NMD process. Furthermore, the ability to produce recombinant RNUT1 protein allows for detailed biochemical characterization and functional assays, facilitating the understanding of its role in mRNA surveillance and its broader implications in cellular processes. As research continues to explore RNUT1's multifaceted roles, understanding its dynamics may reveal novel insights into gene regulation and the molecular underpinnings of diseases associated with NMD dysfunction. Therefore, investigating the recombinant RNUT1 protein not only enhances our fundamental knowledge of RNA metabolism but also paves the way for potential advances in therapeutic strategies targeting NMD-related diseases.
