Cat: PA2000-6545

Recombinant Human CCNB3 Protein,GST

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Analytical Data

  • 基因名

    CCNB3

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CCNB3; CYCB3G2/mitotic-specific cyclin-B3

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    GST-tag at N-terminal

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q8WWL7

  • 表达区间

    1296-1395aa

  • 氨基酸序列

    VQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL

  • 分子量

    36.74 KDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CCNB3, or Cyclin B3, is a member of the cyclin family involved in cell cycle regulation, particularly in the transition from the G2 phase to mitosis. It has garnered significant attention in cancer research due to its potential role in tumorigenesis and cell proliferation. Studies have shown that CCNB3 is overexpressed in various tumors, suggesting it may serve as a biomarker for cancer diagnosis or prognosis, as well as a potential therapeutic target. The protein's distinct expression patterns during meiosis and mitosis further imply its involvement in germ cell development and reproductive biology. Additionally, research has indicated that CCNB3 interacts with various cyclin-dependent kinases (CDKs), influencing the phosphorylation of critical substrates necessary for cell division. Given its pivotal role in cell cycle control and its association with cancer, the recombinant expression and characterization of CCNB3 becomes crucial. Investigating its structure and function through recombinant protein technology enables a better understanding of its mechanisms and interactions, paving the way for novel cancer therapies and interventions targeting cyclin-dependent pathways. As such, CCNB3 is a promising candidate for further exploration in both fundamental research and clinical applications, highlighting the need for continued studies into its biochemical properties and potential as a drug target.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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