Analytical Data
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Gene name
RMND5B
- Application
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Alternative Names
RMND5B; UNQ2508/PRO5996; E3 ubiquitin-protein transferase RMND5B; EC 2.3.2.27; Protein RMD5 homolog B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96G75
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Expression Region
1-393 aa
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AA Sequence
MEQCACVERE LDKVLQKFLT YGQHCERSLE ELLHYVGQLR AELASAALQG TPLSATLSLV MSQCCRKIKD TVQKLASDHK DIHSSVSRVG KAIDRNFDSE ICGVVSDAVW DAREQQQQIL QMAIVEHLYQ QGMLSVAEEL CQESTLNVDL DFKQPFLELN RILEALHEQD LGPALEWAVS HRQRLLELNS SLEFKLHRLH FIRLLAGGPA KQLEALSYAR HFQPFARLHQ REIQVMMGSL VYLRLGLEKS PYCHLLDSSH WAEICETFTR DACSLLGLSV ESPLSVSFAS GCVALPVLMN IKAVIEQRQC TGVWNHKDEL PIEIELGMKC WYHSVFACPI LRQQTSDSNP PIKLICGHVI SRDALNKLIN GGKLKCPYCP MEQNPADGKR IIF
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Molecular Weight
44.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RMND5B, a protein associated with mitochondrial function and cellular metabolism, has garnered attention due to its potential role in various biological processes and diseases, including cancer and neurodegenerative disorders. As a member of the RMND5 family, RMND5B is known to participate in mitochondrial ribosome biogenesis and protein synthesis, which are critical for maintaining mitochondrial integrity and function. Recent studies have suggested that aberrations in RMND5B levels can impact cellular energy production and oxidative stress responses, thus contributing to the pathophysiology of certain diseases. Moreover, its involvement in signal transduction pathways and potential interactions with other cellular proteins highlight its significance in cellular homeostasis. Researchers are increasingly focused on characterizing RMND5B through recombinant protein techniques to elucidate its structure-function relationship, investigate its interaction with mitochondrial components, and explore its therapeutic potential. Understanding RMND5B’s mechanisms of action could provide valuable insights into mitochondrial dysfunction and pave the way for novel interventions in related diseases.
