Analytical Data
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Gene name
RMI2
- Application
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Alternative Names
BLAP18; BLM-associated protein of 18 kDa; C16orf75; hRMI2; MGC24665; RecQ-mediated genome instability protein 2; RMI2; RMI2_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96E14
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Expression Region
2-147 aa
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AA Sequence
AAAADSFSG GPAGVRLPRS PPLKVLAEQL RRDAEGGPGA WRLSRAAAGR GPLDLAAVWM QGRVVMADRG EARLRDPSGD FSVRGLERVP RGRPCLVPGK YVMVMGVVQA CSPEPCLQAV KMTDLSDNPI HESMWELEVE DLHRNIP
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Molecular Weight
15.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RMI2 (RecQ-mediated genome instability 2) is a protein implicated in maintaining genomic stability and facilitating the resolution of stalled replication forks, which are critical for preventing cellular stress and genomic instability. Research into RMI2 has gained momentum due to its association with various cancer types, particularly hereditary breast and ovarian cancers. It is part of a larger complex that includes other key proteins such as BLM (Bloom syndrome protein) and TOP3α (Topoisomerase IIIα), functioning synergistically to ensure proper DNA replication and repair processes. Mutations or altered expressions of RMI2 can lead to defective DNA repair mechanisms, resulting in an increased risk of tumorigenesis. Given its essential role in genomic maintenance and its potential as a biomarker or therapeutic target in cancer treatments, understanding the structure, function, and regulatory mechanisms of RMI2 is crucial. Research into RMI2 not only enhances our comprehension of fundamental DNA repair pathways but also opens new avenues for targeted cancer therapies that aim at restoring normal cellular functions by modulating the activity of this vital protein. Thus, RMI2 represents a promising subject of investigation in molecular biology and cancer research.
