Analytical Data
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Gene name
CCDC11
- Application
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Alternative Names
4933415I03Rik; CCD11_HUMAN; CCDC11; Cilia and flagella associated Protein 53; Coiled coil domain containing 11; Coiled coil domain containing Protein 11; Coiled-coil domain-containing Protein 11; FLJ32743; HTX6; MGC117752; RGD1306734
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96M91
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Expression Region
1-399aa
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AA Sequence
MQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP
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Molecular Weight
74.8 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCDC11, or Coiled-Coil Domain Containing 11, is a protein that plays a significant role in various cellular processes, including intracellular transport, ciliary formation, and mitotic spindle organization. Recent studies have indicated that mutations or dysregulation of CCDC11 may be associated with human diseases, particularly those affecting the cilia, such as ciliopathies, which can lead to severe developmental disorders, including renal, respiratory, and neurological issues. Given its critical functions, there is a growing interest in understanding the molecular mechanisms underlying CCDC11's role in cellular contexts. The investigation of its structure and function through the generation of recombinant proteins has been pivotal in elucidating these mechanisms. Recombinant CCDC11 proteins are being used to study its interactions with other cellular components and to explore its potential as a therapeutic target. Furthermore, characterizing CCDC11's structure can provide insights into its functional domains and how alterations in these domains may contribute to disease phenotypes. This research not only enhances our understanding of the fundamental biology of CCDC11 but also opens up avenues for potential clinical applications in diagnosing and treating conditions linked to its dysfunction. The development of CCDC11 recombinant proteins is, therefore, a critical step towards advancing our knowledge of its roles in health and disease.
