Analytical Data
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Gene name
RHPN2
- Application
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Alternative Names
76 kDa RhoB effector protein; D7Ertd784e; GTP Rho binding protein 2; GTP-Rho-binding protein 2; p76RBE; Rho GTPase binding protein 2; RhoB effector; RhoBP; Rhophilin 2; Rhophilin; Rhophilin like protein; Rhophilin like Rho GTPase binding protein ; Rhophilin Rho GTPase binding protein 2; Rhophilin-2; Rhophilin2; RHPN 2; RHPN2; RHPN2_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IUC4
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Expression Region
1-686 aa
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AA Sequence
MTDALLPAAP QPLEKENDGY FRKGCNPLAQ TGRSKLQNQR AALNQQILKA VRMRTGAENL LKVATNSKVR EQVRLELSFV NSDLQMLKEE LEGLNISVGV YQNTEEAFTI PLIPLGLKET KDVDFAVVLK DFILEHYSED GYLYEDEIAD LMDLRQACRT PSRDEAGVEL LMTYFIQLGF VESRFFPPTR QMGLLFTWYD SLTGVPVSQQ NLLLEKASVL FNTGALYTQI GTRCDRQTQA GLESAIDAFQ RAAGVLNYLK DTFTHTPSYD MSPAMLSVLV KMMLAQAQES VFEKISLPGI RNEFFMLVKV AQEAAKVGEV YQQLHAAMSQ APVKENIPYS WASLACVKAH HYAALAHYFT AILLIDHQVK PGTDLDHQEK CLSQLYDHMP EGLTPLATLK NDQQRRQLGK SHLRRAMAHH EESVREASLC KKLRSIEVLQ KVLCAAQERS RLTYAQHQEE DDLLNLIDAP SVVAKTEQEV DIILPQFSKL TVTDFFQKLG PLSVFSANKR WTPPRSIRFT AEEGDLGFTL RGNAPVQVHF LDPYCSASVA GAREGDYIVS IQLVDCKWLT LSEVMKLLKS FGEDEIEMKV VSLLDSTSSM HNKSATYSVG MQKTYSMICL AIDDDDKTDK TKKISKKLSF LSWGTNKNRQ KSASTLCLPS VGAARPQVKK KLPSPFSLLN SDSSWY
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Molecular Weight
76.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RHPN2, or Rho GTPase-activated protein 2, is a member of the RHPN family of proteins, which play crucial roles in various cellular processes, including cytoskeletal dynamics, cell adhesion, and signal transduction. Research into RHPN2 has gained interest due to its involvement in several pathological conditions, including cancer metastasis and neurological disorders. Dysregulation of RHPN2 expression and function can disrupt normal cellular processes, leading to aberrant cell behavior. Recent studies have indicated that RHPN2 interacts with the Rho family of GTPases, serving as a potential regulator of actin cytoskeleton remodeling and influencing cell shape and movement. Furthermore, the exploration of RHPN2 as a therapeutic target is gaining traction, as understanding its mechanistic roles could open new avenues for developing interventions in diseases where RHPN2 is implicated. Recombinant protein studies involving RHPN2 are essential for elucidating its structure-function relationships, interaction networks, and downstream effects, thereby contributing to a comprehensive understanding of its biological significance and potential as a drug target.
