Analytical Data
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Gene name
RHPN1
- Application
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Alternative Names
GTP Rho binding protein 1; GTP-Rho-binding protein 1; ODF5 ; Outer dense fiber of sperm tails 5 ; Rhophilin 1 ; Rhophilin-1; RHPN ; Rhpn1; RHPN1_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TCX5
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Expression Region
1-695 aa
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AA Sequence
MILEERPDGA GAGEESPRLQ GCDSLTQIQC GQLQSRRAQI HQQIDKELQM RTGAENLYRA TSNNRVRETV ALELSYVNSN LQLLKEELEE LSGGVDPGRH GSEAVTVPMI PLGLKETKEL DWSTPLKELI SVHFGEDGAS YEAEIRELEA LRQAMRTPSR NESGLELLTA YYNQLCFLDA RFLTPARSLG LFFHWYDSLT GVPAQQRALA FEKGSVLFNI GALHTQIGAR QDRSCTEGAR RAMEAFQRAA GAFSLLRENF SHAPSPDMSA ASLCALEQLM MAQAQECVFE GLSPPASMAP QDCLAQLRLA QEAAQVAAEY RLVHRTMAQP PVHDYVPVSW TALVHVKAEY FRSLAHYHVA MALCDGSREC PPHLPMVLPR PPRAGSQPLC PPAATEGELP THEQVFLQPP TSSKPRGPVL PQELEERRQL GKAHLKRAIL GQEEALRLHA LCRVLREVDL LRAVISQTLQ RSLAKYAELD REDDFCEAAE APDIQPKTHQ KPEARMPRLS QGKGPDIFHR LGPLSVFSAK NRWRLVGPVH LTRGEGGFGL TLRGDSPVLI AAVIPGSQAA AAGLKEGDYI VSVNGQPCRW WRHAEVVTEL KAAGEAGASL QVVSLLPSSR LPSLGDRRPV LLGPRGLLRS QREHGCKTPA STWASPRPLL NWSRKAQQGK TGGCPQPCAP VKPAPPSSLK HPGWP
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Molecular Weight
73.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RHPN1, or Rhophilin Rho GTPase-binding protein 1, is a member of the rhophilin protein family, which is known to interact with Rho GTPases, a group of signaling molecules that regulate various cellular processes including cytoskeletal dynamics, cell motility, and proliferation. The protein plays a crucial role in cellular signaling pathways by modulating the Rho GTPase activity, particularly in the context of synaptic functions and neuronal development. Research has indicated that dysregulation of RHPN1 may be linked to several pathological conditions, including neurological disorders and cancer. The study of RHPN1 recombinant protein has garnered attention as it provides insights into its functional mechanisms and interactions within cells. By producing and characterizing RHPN1 as a recombinant protein, researchers aim to elucidate its structural properties and binding affinities with Rho GTPases, thus paving the way for potential therapeutic interventions. Furthermore, the exploration of RHPN1's role in cellular signaling and its implications in disease models could lead to novel approaches in treating conditions associated with Rho GTPase dysregulation. This includes the need to better understand its mechanisms in order to potentially target these pathways for therapeutic gain, making RHPN1 a protein of significant interest in biomedical research.
