Analytical Data
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Gene name
CBWD1
- Application
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Alternative Names
Cbwd1; CBWD1_HUMAN; Cobalamin synthase W domain-containing Protein 1; Cobalamin synthetase W domain containing Protein 1; COBP; COBW domain containing 1; COBW domain-containing Protein 1; COBW like Protein; NPC-A-6; NPC-A-6 COBW domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BRT8
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Expression Region
1-395aa
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AA Sequence
MYFKRAARAFPVLLTGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTRFQEDQVCT
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Molecular Weight
66.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBWD1, or C-blind domain-containing protein 1, has garnered increasing attention in recent years due to its potential roles in cellular processes and disease mechanisms. This protein is known to participate in various cellular pathways, including those involved in DNA repair, cell cycle regulation, and apoptosis. Recent studies suggest that CBWD1 may interact with key proteins implicated in tumorigenesis, making it a subject of interest for cancer research. The recombinant expression of CBWD1 allows for detailed investigation of its structure-function relationship and interactions with other biomolecules. Researchers have utilized various expression systems, such as bacterial and eukaryotic systems, to obtain functional protein for biochemical assays and structural studies. Understanding the precise biological roles of CBWD1 through its recombinant form could unveil new therapeutic targets and diagnostic markers for diseases, particularly cancers where CBWD1 dysregulation is implicated. Moreover, elucidating the molecular mechanisms by which CBWD1 exerts its effects may contribute to broader insights into cellular homeostasis and disease pathology. Ongoing studies aim to characterize the protein's post-translational modifications and its influence on cellular signaling networks, thereby expanding our knowledge of its biological significance and potential applications in biomedicine.
