Analytical Data
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Gene name
CASC4
- Application
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Alternative Names
Cancer susceptibility candidate 4; Cancer susceptibility candidate gene 4 Protein; CASC4; CASC4_HUMAN; DKFZp459F1927; Gene associated with HER-2/neu overexpression; H63; MGC74708; Protein CASC4
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P4E1
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Expression Region
1-436aa
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AA Sequence
MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL
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Molecular Weight
75.9 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CASC4, or Cancer Susceptibility 4, is a protein that has garnered attention in recent years due to its potential role in cancer biology and cellular processes. Found to be essential for the regulation of multiple cellular functions, CASC4 has been implicated in various cancer types, suggesting a possible involvement in tumorigenesis and cancer progression. Its association with RNA processing and the maintenance of genome integrity highlights its importance in cellular homeostasis. Researchers have focused on understanding CASC4's mechanisms of action, including its interactions with other proteins and RNA molecules, to unravel its role in promoting or inhibiting cancerous behaviors. Studies utilizing recombinant CASC4 protein have enabled scientists to elucidate its functional properties and investigate its potential as a therapeutic target. Furthermore, by exploring the molecular pathways influenced by CASC4, researchers aim to identify novel biomarkers for cancer diagnosis and prognosis, as well as innovative strategies for treatment. Given the increasing incidence of cancer worldwide, understanding the implications of CASC4 and other similar proteins could pave the way for future advancements in personalized medicine and targeted therapies. As research progresses, the insights gained from studying CASC4 may contribute significantly to the broader field of cancer biology and therapeutic development.
