Analytical Data
-
Gene name
RGS11
- Application
-
Alternative Names
Regulator of G protein signaling 11 ; Regulator of G protein signalling 11 ; Regulator of G-protein signaling 11; RGS 11; RGS11; RGS11_HUMAN; RS 11; RS11
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O94810
-
Expression Region
1-467 aa
-
AA Sequence
MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA
-
Molecular Weight
52.9 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RGS11 (Regulator of G-Protein Signaling 11) is a member of the RGS protein family, which plays a critical role in regulating G-protein-coupled receptor (GPCR) signaling pathways. These pathways are integral to numerous physiological processes, including neurotransmission, immune responses, and cell proliferation. Dysregulation of RGS proteins, including RGS11, has been implicated in various diseases, such as cancer, cardiovascular disorders, and neurodegenerative conditions. The ability of RGS11 to modulate G-protein activity makes it an attractive target for pharmacological intervention. Research on recombinant RGS11 protein is crucial for understanding its molecular mechanisms and functions in signal transduction. By producing and purifying RGS11 through recombinant techniques, scientists can study its interaction with different G-proteins and GPCRs in vitro, unraveling the complexities of GPCR signaling regulation. Such studies not only provide insights into RGS11's biological roles but also pave the way for the development of novel therapeutic approaches targeting RGS proteins. Understanding the structure-function relationship of RGS11 could lead to the discovery of small molecules that could modulate its activity, thereby influencing GPCR signaling pathways in a disease-specific manner. As a result, RGS11 recombinant protein research holds significant potential for advancing our knowledge of cellular signaling and developing new strategies for treating diseases linked to GPCR dysfunction.
