Analytical Data
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Gene name
US12
- Application
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Alternative Names
US12；Small ribosomal subunit Protein uS12
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P03170
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Expression Region
1-88aa
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AA Sequence
MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR
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Molecular Weight
11.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The US12 protein is a key component of the virulence factor in various herpesviruses, particularly in the context of human cytomegalovirus (HCMV). Research into US12 focuses on its role in modulating host immune responses, specifically in how it may facilitate viral persistence and evasion of the host's immune system. US12 is known to be involved in the interaction with cellular proteins that influence the immune signaling pathways, thereby allowing the virus to establish a latent infection. Given the clinical implications of herpesvirus infections, particularly in immunocompromised individuals and organ transplant recipients, understanding the function and mechanisms of US12 is critical. It has been observed that US12 can affect the expression of chemokines and other molecules essential for immune surveillance. Moreover, studies have indicated that manipulating US12 may provide therapeutic opportunities, either by restoring immune function or by developing targeted antiviral strategies. The ongoing research on US12 aims to elucidate its precise biological functions and interactions within the host cell, which could potentially lead to novel interventions against herpesvirus-related diseases.
