Analytical Data
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基因名
RFXAP
- Application
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别名
Regulatory factor X associated protein; Regulatory factor X-associated protein; RFX associated protein; RFX DNA binding complex 36 kDa subunit; RFX DNA-binding complex 36 kDa subunit; RFX-associated protein; RFXAP; RFXAP_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00287
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表达区间
1-272 aa
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氨基酸序列
MEAQGVAEGA GPGAASGVPH PAALAPAAAP TLAPASVAAA ASQFTLLVMQ PCAGQDEAAA PGGSVGAGKP VRYLCEGAGD GEEEAGEDEA DLLDTSDPPG GGESAASLED LEDEETHSGG EGSSGGARRR GSGGGSMSKT CTYEGCSETT SQVAKQRKPW MCKKHRNKMY KDKYKKKKSD QALNCGGTAS TGSAGNVKLE ESADNILSIV KQRTGSFGDR PARPTLLEQV LNQKRLSLLR SPEVVQFLQK QQQLLNQQVL EQRQQQFPGT SM
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分子量
28.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RFXAP (Regulatory Factor X Associated Protein) is a crucial component in the immune system's MHC (Major Histocompatibility Complex) class II pathway, playing a significant role in the regulation of gene expression involved in antigen presentation. MHC class II molecules are essential for the activation of CD4+ T cells, making them vital for adaptive immunity. Deficiencies or dysfunctions in RFXAP can lead to immune disorders, particularly affecting the body's ability to respond to pathogens. Research into the recombinant production of RFXAP has gained traction due to its importance in understanding the mechanisms of immune response and its potential implications in autoimmune diseases and immunodeficiencies. By studying RFXAP in a recombinant form, scientists aim to elucidate its structure-function relationship, explore its interactions with other protein complexes, and investigate its role in MHC class II gene regulation. This research not only enhances our understanding of immune regulation but also paves the way for therapeutic interventions that may target or modulate RFXAP functions, providing avenues for the development of new treatments for various immune-related conditions. Thus, the study of RFXAP recombinant proteins is of paramount importance in both basic immunology and clinical applications, highlighting its potential as a key target in the manipulation of immune responses.
