Analytical Data
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基因名
CAPZA3
- Application
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别名
CAPZA3; CAPAA3; GSG3F-actin-capping Protein subunit alpha-3; CapZ alpha-3; CP-alpha-3; Germ cell-specific Protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96KX2
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表达区间
1-299aa
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氨基酸序列
MTLSVLSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYSVPLCIDGNPVLLSHHNVMGDYRFFDHQSKLSFKYYLLQNQLKDIQSHGIIQNEAEYLRVVLLCALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVNPFLTQVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEELQELSNEALRKILRRDLPVTRTLIDWHRILSDLNLVMYPKLGYVIYSRSVLCNWII
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分子量
61.5 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAPZA3, a member of the CapZ protein family, plays a crucial role in the regulation of actin filament dynamics, which is vital for various cellular processes such as motility, shape maintenance, and cell division. The CAPZA proteins are actin-capping proteins that bind to the barbed ends of actin filaments, preventing further polymerization and thus regulating the filament's growth and stability. Recent studies have indicated that CAPZA3, in particular, may be involved in critical cellular functions and signaling pathways, making it an important focus of research in cell biology and cancer studies. Its dysregulation has been implicated in various diseases, including cancer metastasis and progression, where altered actin dynamics contribute to increased cellular motility and invasion. Understanding the structure and function of CAPZA3 through recombinant protein studies could provide insights into its role in these pathological processes. Furthermore, elucidating the molecular mechanisms governing CAPZA3's interactions with actin and other cellular components might reveal potential therapeutic targets for diseases associated with aberrant actin regulation. Given the significance of actin dynamics in diverse biological processes, CAPZA3 remains a pertinent subject of investigation in the context of cytoskeletal regulation and its implications in health and disease.
