Analytical Data
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Gene name
FAM20B
- Application
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Alternative Names
FAM20B；KIAA0475；Glycosaminoglycan xylosylkinase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75063
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Expression Region
31-409aa
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AA Sequence
SAANREDQRA FHRMMTGLRV ELAPKLDHTL QSPWEIAAQW VVPREVYPEE TPELGAVMHA MATKKIIKAD VGYKGTQLKA LLILEGGQKV VFKPKRYSRD HVVEGEPYAG YDRHNAEVAA FHLDRILGFH RAPLVVGRFV NLRTEIKPVA TEQLLSTFLT VGNNTCFYGK CYYCRETEPA CADGDIMEGS VTLWLPDVWP LQKHRHPWGR TYREGKLARW EYDESYCDAV KKTSPYDSGP RLLDIIDTAV FDYLIGNADR HHYESFQDDE GASMLILLDN AKSFGNPSLD ERSILAPLYQ CCIIRVSTWN RLNYLKNGVL KSALKSAMAH DPISPVLSDP HLDAVDQRLL SVLATVKQCT DQFGMDTVLV EDRMPLSHL
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Molecular Weight
71 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FAM20B is a gene that encodes a protein involved in the phosphorylation of secreted proteins, particularly in the context of mineralization and bone development. Research into FAM20B has gained significance due to its crucial role in processes such as osteogenesis, tooth development, and extracellular matrix mineralization. Mutations in FAM20B are associated with certain dental and skeletal disorders, including the enamel hypoplasia seen in patients with FAM20B-related human diseases. Understanding the structure and function of FAM20B protein is vital for elucidating its mechanisms in cellular signaling and its impact on bone and dental health. Recent studies have focused on the biochemical characterization of FAM20B, exploring its enzymatic activity, phosphorylation targets, and interaction with other proteins in signaling pathways. The research is not only aimed at understanding normal physiological roles but also at developing potential therapeutic strategies for disorders linked to FAM20B mutations. By constructing recombinant FAM20B proteins and analyzing their functions in vitro, researchers are uncovering insights into how FAM20B mutations lead to pathological conditions, ultimately paving the way for innovative approaches in regenerative medicine and tissue engineering.
