Analytical Data
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Gene name
RCAN2
- Application
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Alternative Names
Calcipressin 2; Calcipressin-2; CSP2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1 like 1 protein; DSCR1L1; MCIP2; Myocyte enriched calcineurin interacting protein 2; Myocyte-enriched calcineurin-interacting protein 2; RCAN2; RCAN2_HUMAN; RCN2; Regulator of calcineurin 2; Thyroid hormone responsive gene ZAKI4; Thyroid hormone responsive protein ZAKI4; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4; ZAKI4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14206
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Expression Region
1-197 aa
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AA Sequence
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN
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Molecular Weight
21.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RCAN2 (Regulator of Calcineurin 2) is a critical protein that plays significant roles in various cellular processes, including calcium signaling, neuronal differentiation, and stress responses. It is a member of the RCAN family, which is known for modulating the activity of calcineurin, a calcium-dependent phosphatase that influences numerous signaling pathways. The dysregulation of RCAN2 has been associated with several pathological conditions, including neurodegenerative diseases, cardiovascular disorders, and certain cancers. Research has shown that RCAN2 can affect the transcriptional activity of NFAT (Nuclear Factor of Activated T-cells), a crucial factor in immune responses and cardiac development. Consequently, understanding the molecular mechanisms underlying RCAN2's functionality could reveal new therapeutic targets for these diseases. Recombinant RCAN2 protein studies facilitate the elucidation of its structure-function relationship, interactions with calcineurin, and its downstream signaling pathways. This research not only provides insights into the fundamental biology of RCAN2 but also paves the way for potential clinical applications, as manipulating RCAN2 levels or activity may offer novel strategies for treatment in conditions where calcium signaling is disrupted.
