Analytical Data
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Gene name
C9orf64
- Application
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Alternative Names
C9orf64; CI064_HUMAN; UPF0553 Protein C9orf64
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5T6V5
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Expression Region
1-160aa
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AA Sequence
MHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY
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Molecular Weight
45.1 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C9orf64, a gene located on chromosome 9, has garnered interest in recent years due to its potential role in various biological processes and diseases. Initial studies suggested its involvement in neurodegenerative disorders, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where mutations in related genes have been linked to altered cellular functions. The structured protein encoded by C9orf64 has been hypothesized to participate in critical cellular pathways, including inflammation and neuroprotection. Researchers have focused on generating recombinant C9orf64 protein to elucidate its functional properties and interactions with other cellular molecules. The production of this protein in heterologous systems, such as bacterial or yeast models, allows for detailed biochemical characterization and the exploration of its role in protein networks. Understanding C9orf64's structure and function could pave the way for identifying novel therapeutic targets and strategies for managing conditions associated with its dysfunction. Additionally, exploring its expression patterns across different tissues may reveal insights into its physiological roles and implications in broader biological contexts. This research endeavor represents a significant stride in comprehending the molecular underpinnings of complex diseases and may contribute to advancements in precision medicine.
