Analytical Data
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Gene name
C9orf68
- Application
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Alternative Names
SPATA6L; C9orf68; Spermatogenesis associated 6-like Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N4H0
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Expression Region
1-392aa
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AA Sequence
MPLEVVVELQIRAISCPGVFLPGKQDVYLGVYLMNQYLETNSFPSAFPIMIQESMRFEKVFESAVDPGAVVDLLEMWDELAYYEENTRDFLFPEPKLTPSHPRRCREVLMKTALGFPGIAPKIEFSTRTAIRECVFLHRNRFLEERHESRRPLSTSHEPIFPLNTIKMKLRENNLNRLPKGMQARAPSQYSTRHFFQDQPAQLNLGNNFKISGGSKPPFVVRHVDSAKPFGENISEHHLRRSGRKSKFSDFPFPTRRASSLDSLAANVKVIKEPDERIVLRSDSSSCLDSSQFGKSSSSKQGDADFHGKASFATYQHSTSPGPLDQPLLRERFHPGSQSTWKNIHERVCSLLTSHRAQLHQNKEDSTSEVNYIIERPSYPLKKYSLHEQRYF
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Molecular Weight
71.4 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C9orf68, a gene located on chromosome 9, has garnered attention due to its potential implications in various cellular processes and diseases. Initial interest in C9orf68 arose from its association with neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where it was identified as a candidate gene linked to these conditions via genome-wide association studies. The protein encoded by C9orf68 is believed to play critical roles in cellular functions such as lipid metabolism, cellular signaling, and neuronal development; however, its precise mechanisms of action remain poorly understood. Researchers have focused on producing recombinant C9orf68 protein to facilitate detailed biochemical and structural studies. These studies aim to elucidate the protein's functional roles and interactions within the cell, as well as its potential impact on disease pathogenesis. Understanding the structure and function of C9orf68 could provide insights into therapeutic strategies for neurodegenerative conditions, highlighting its significance in both basic and translational research contexts. Given the increasing recognition of its importance, ongoing investigations into C9orf68 will not only enhance our understanding of its biological roles but also pave the way for novel interventions aimed at mitigating the effects of the diseases with which it is associated.
