Analytical Data
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Gene name
CRABP2
- Application
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Alternative Names
CRABP2；Cellular retinoic acid-binding Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29373
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Expression Region
1-138aa
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AA Sequence
MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CRABP2, or Cellular Retinoic Acid Binding Protein 2, is a member of the retinoid binding protein family that plays a pivotal role in the transport and metabolism of retinoic acid, a crucial derivative of vitamin A involved in numerous cellular processes, including growth, differentiation, and apoptosis. The significance of CRABP2 in retinoic acid signaling has garnered interest due to its implications in various physiological and pathological conditions, including embryonic development, skin health, and cancer progression. Studies have shown that CRABP2 can influence the activity of retinoic acid receptors, thereby modulating gene expression in response to retinoid signaling. Given its role in regulating these pathways, CRABP2 has been identified as a potential therapeutic target for disorders related to retinoic acid dysregulation. Recent research focuses on the structural and functional characterization of CRABP2 recombinant proteins, which can provide valuable insights into the binding affinities and interaction dynamics with retinoic acid and its receptors. Understanding the mechanisms by which CRABP2 mediates its effects may lead to novel strategies for intervention in diseases where retinoid signaling is disrupted. Furthermore, the production and study of CRABP2 recombinant proteins enable researchers to explore its biophysical properties, interactions with other proteins, and potential applications in drug development, making it a subject of considerable interest in molecular biology and pharmacology.
