Cat: PA2000-6382

Recombinant Human C9orf3 Protein,GST

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Analytical Data

  • Gene name

    C9orf3

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CNTLN; C9orf101; C9orf39Centlein; Centrosomal Protein

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8IYR6

  • Expression Region

    1-223aa

  • AA Sequence

    MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR

  • Molecular Weight

    51.8 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

C9orf3, a gene located on chromosome 9, has garnered attention in recent years due to its potential roles in various biological processes and its implications in human diseases. Research indicates that C9orf3 may be involved in cellular functions such as proliferation, differentiation, and cellular signaling pathways, suggesting that it might play a crucial role in maintaining cellular homeostasis. The protein product, C9orf3, is believed to interact with other cellular components, influencing critical biological functions. Furthermore, emerging studies have associated C9orf3 with neurodegenerative diseases, drawing interest from researchers seeking to understand its role in the pathogenesis of conditions like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Given these associations, the recombinant expression of C9orf3 is becoming increasingly vital for dissecting its functional properties and elucidating its mechanisms of action. Investigating C9orf3 through recombinant protein techniques not only aids in clarifying its biological roles but also opens avenues for potential therapeutic interventions targeting the pathways it influences. Such studies hold promise for providing insights into how C9orf3 could be manipulated for medical advancements, particularly in the context of neurodegenerative disease treatments. Therefore, the characterization and functional analysis of C9orf3 as a recombinant protein is a crucial area of ongoing research, paving the way for future discoveries in molecular biology and medicine.

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