Analytical Data
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Gene name
CLK3
- Application
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Alternative Names
CLK3；Dual specificity Protein kinase CLK3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49761
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Expression Region
1-490aa
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AA Sequence
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER SFHTSRNPSR
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CLK3, or Clock protein 3, is a member of the CLK gene family that plays a crucial role in the circadian rhythm regulation in mammals. Circadian rhythms are essential biological processes that follow a roughly 24-hour cycle, impacting various physiological functions such as sleep, metabolism, and hormone release. Research has shown that CLK3, like other clock genes, is involved in the transcriptional and translational feedback loops that maintain these rhythmic processes. Abnormalities in circadian regulation have been linked to various health issues, including sleep disorders, metabolic syndromes, and even mood disorders. Recent studies focus on characterizing CLK3's specific functions and its interactions with other clock-related proteins to better understand its role in maintaining circadian timing. Understanding CLK3's mechanisms could provide insights into potential therapeutic targets for diseases related to circadian rhythm disruptions. Additionally, investigating CLK3's role beyond the brain, in peripheral tissues, is emerging as a significant area of interest, as it may influence systemic metabolic processes and overall health. The exploration of CLK3's molecular pathways and regulatory mechanisms continues to evolve, highlighting its potential significance in both basic biology and clinical applications.
