Analytical Data
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基因名
RAB3IP
- Application
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别名
Gtpat12; Rab-3A-interacting protein; RAB3A interacting protein ; RAB3A interacting protein (rabin3); RAB3A interacting protein; RAB3A-interacting protein; RAB3I_HUMAN; Rab3ip; Rabin 3; Rabin-3; RABIN3; RABIN3; rat; homolog of; Rabin8; SSX2 interacting protein ; SSX2 interacting protein; SSX2-interacting protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96QF0
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表达区间
1-476 aa
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氨基酸序列
MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT TSPSVIYRPH PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS FHVTDPAPCS TSGVTAGLTK LTTRKDNYNA EREFLQGATI TEACDGSDDI FGLSTDSLSR LRSPSVLEVR EKGYERLKEE LAKAQRELKL KDEECERLSK VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE AQGKIDVLQA EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT FSKSELASAV LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ SKSCKHRIKL GDSSNYYYIS PFCRYRITSV CNFFTYIRYI QQGLVKQQDV DQMFWEVMQL RKEMSLAKLG YFKEEL
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分子量
53.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB3IP, a member of the RAB protein family, plays a crucial role in intracellular vesicle trafficking and membrane dynamics. With its involvement in the regulation of exocytosis and endocytosis, RAB3IP is implicated in various cellular processes, including neurotransmitter release and insulin secretion. Dysregulation of RAB3IP has been associated with several pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders. Recent studies have highlighted its potential role as a biomarker for certain cancers and its contribution to the pathophysiology of diseases such as Alzheimer’s, where it may influence synaptic function and neuronal survival. Given its pivotal functions, RAB3IP has attracted considerable research interest, focusing on understanding its molecular mechanisms and interactions with other proteins within the RAB family. The reconstitution of RAB3IP as a recombinant protein offers a valuable tool for evaluating its functional properties, determining its biochemical pathways, and exploring its potential as a therapeutic target. Research in this area aims to elucidate how RAB3IP affects cellular signaling and organelle communication, thereby providing insights into both normal physiological processes and disease mechanisms. Understanding RAB3IP's role could lead to novel therapeutic strategies that target vesicular trafficking pathways to ameliorate diseases associated with its dysfunction.
