Analytical Data
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Gene name
PSMG1
- Application
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Alternative Names
PSMG1; C21LRP; DSCR2; PAC1; Proteasome assembly chaperone 1; PAC-1; Chromosome 21 leucine-rich protein; C21-LRP; Down syndrome critical region protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95456
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Expression Region
2-288 aa
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AA Sequence
AATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT
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Molecular Weight
32.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMG1, also known as proteasome subunit beta type, is a crucial component of the 26S proteasome, a large proteolytic complex responsible for degrading ubiquitinated proteins in eukaryotic cells. The proteasome plays a vital role in cellular homeostasis, regulating various processes such as the cell cycle, apoptosis, and responses to stress, making its subunits essential for maintaining proper cellular function. Research on PSMG1 has gained attention due to its involvement in protein quality control and its potential implications in various diseases, including cancer and neurodegenerative disorders. Abnormalities in proteasome function can lead to the accumulation of damaged or misfolded proteins, contributing to the pathogenesis of these conditions. Moreover, alterations in PSMG1 expression levels have been correlated with tumor progression and poor prognosis in certain cancers, suggesting that PSMG1 could serve as a potential biomarker or therapeutic target. Consequently, understanding the structure, function, and regulatory mechanisms of PSMG1 is critical for elucidating its role in proteasome activity and its impact on disease mechanisms, paving the way for novel interventions aimed at modulating proteasome function in various therapeutic contexts.
