Analytical Data
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Gene name
RBFOX2
- Application
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Alternative Names
RBFOX2；ESR；NR3A1；Estrogen receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43251
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Expression Region
1-380aa
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AA Sequence
MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY
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Molecular Weight
44.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RBFOX2 is a member of the RNA-binding Fox (RBFOX) family, playing a crucial role in regulating alternative splicing and the stability of target mRNAs. It is primarily expressed in the nervous system and is essential for neuronal differentiation and synaptic function. Aberrant expression of RBFOX2 has been implicated in various neurodevelopmental disorders and malignancies, particularly in the context of brain tumors and certain types of cancer. Recent studies have highlighted its influence on the splicing of pre-mRNAs involved in neuronal signaling and cellular growth, revealing its potential as a therapeutic target. Understanding the structure and function of RBFOX2, as well as the mechanisms underlying its action in cellular contexts, is essential for elucidating its role in health and disease. The development of recombinant RBFOX2 protein allows researchers to investigate its biochemical properties, binding affinities, and effects on RNA splicing in vitro and in vivo. By characterizing this protein, scientists aim to uncover insights into its regulatory networks and how its dysregulation affects cellular processes, which could ultimately lead to novel strategies for treating diseases associated with RBFOX2 malfunction.
