Analytical Data
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基因名
PRPS2
- Application
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别名
EC 2.7.6.1; Phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase 2; Phosphoribosyl pyrophosphate synthetase II; PPRibP; Prps2; PRPS2_HUMAN; PRS II; PRS-II; Ribose phosphate pyrophosphokinase II; Ribose-phosphate pyrophosphokinase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11908
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表达区间
2-318 aa
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氨基酸序列
PNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLQWIRENIA EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATKVYAILTH GIFSGPAISR INNAAFEAVV VTNTIPQEDK MKHCTKIQVI DISMILAEAI RRTHNGESVS YLFSHVPL
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分子量
34.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRPS2 (Phosphoribosyl Pyrophosphate Synthetase 2) is an enzyme that plays a critical role in nucleotide metabolism, catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key substrate for the biosynthesis of nucleotides and nucleic acids. Research into PRPS2 has garnered significant attention due to its pivotal function in cellular physiology and its potential implications in various diseases. Mutations in the PRPS2 gene have been linked to disorders such as Arts syndrome, which encompasses a range of neurological symptoms, hearing loss, and other developmental issues. Additionally, aberrations in PRPS2 activity are implicated in metabolic syndromes and cancer, where altered nucleotide synthesis can drive cell proliferation. The study of PRPS2 recombinant protein is essential for understanding its biochemical properties, regulatory mechanisms, and interaction with other cellular pathways. Researchers aim to produce PRPS2 in a recombinant form to facilitate detailed investigations into its structure-function relationships, enzyme kinetics, and potential as a therapeutic target. Advances in this area could lead to novel treatments for diseases associated with PRPS2 dysregulation, highlighting the enzyme's significance in both basic research and clinical applications. Overall, the exploration of PRPS2 and its recombinant protein is a promising frontier in the intersection of biochemistry, genetics, and medicine.
