Analytical Data
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Gene name
PRPS2
- Application
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Alternative Names
EC 2.7.6.1; Phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase 2; Phosphoribosyl pyrophosphate synthetase II; PPRibP; Prps2; PRPS2_HUMAN; PRS II; PRS-II; Ribose phosphate pyrophosphokinase II; Ribose-phosphate pyrophosphokinase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11908
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Expression Region
2-318 aa
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AA Sequence
PNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLQWIRENIA EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATKVYAILTH GIFSGPAISR INNAAFEAVV VTNTIPQEDK MKHCTKIQVI DISMILAEAI RRTHNGESVS YLFSHVPL
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Molecular Weight
34.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRPS2 (Phosphoribosyl Pyrophosphate Synthetase 2) is an enzyme that plays a critical role in nucleotide metabolism, catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key substrate for the biosynthesis of nucleotides and nucleic acids. Research into PRPS2 has garnered significant attention due to its pivotal function in cellular physiology and its potential implications in various diseases. Mutations in the PRPS2 gene have been linked to disorders such as Arts syndrome, which encompasses a range of neurological symptoms, hearing loss, and other developmental issues. Additionally, aberrations in PRPS2 activity are implicated in metabolic syndromes and cancer, where altered nucleotide synthesis can drive cell proliferation. The study of PRPS2 recombinant protein is essential for understanding its biochemical properties, regulatory mechanisms, and interaction with other cellular pathways. Researchers aim to produce PRPS2 in a recombinant form to facilitate detailed investigations into its structure-function relationships, enzyme kinetics, and potential as a therapeutic target. Advances in this area could lead to novel treatments for diseases associated with PRPS2 dysregulation, highlighting the enzyme's significance in both basic research and clinical applications. Overall, the exploration of PRPS2 and its recombinant protein is a promising frontier in the intersection of biochemistry, genetics, and medicine.
