Analytical Data
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基因名
PRPF40A
- Application
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别名
Fas ligand associated factor 1; Fas ligand-associated factor 1; FBP 11; FBP11; FLAF 1; FLAF1; FNBP 3; Formin binding protein 11; Formin binding protein 3; Formin-binding protein 11; Formin-binding protein 3; HIP-10; HIP10; Huntingtin interacting protein A; Huntingtin interacting protein HYPA; Huntingtin yeast partner A; Huntingtin-interacting protein 10; Huntingtin-interacting protein A; HYPA; NY REN 6; NY REN 6 antigen; PR40A_HUMAN; Pre mRNA processing factor 40 homolog A; Pre-mRNA-processing factor 40 homolog A; PRP40 pre mRNA processing factor 40 homolog A (S cerevisiae) ; PRP40 pre mRNA processing factor 40 homolog A (yeast) ; PRP40 pre mRNA processing factor 40 homolog A; PRPF 40A; PRPF40A; Renal carcinoma antigen NY-REN-6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75400
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表达区间
1-215 aa
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氨基酸序列
MKRKESAFKSMLKQAAPPIELDAVWEDIRERFVKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSDSDDDDSHSKKKRQRSESRSASEHSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDAEREKDKKEKDRESEKDRTRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ
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分子量
49.28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRPF40A, or Pre-mRNA Processing Factor 40A, is an essential component of the spliceosome, a complex responsible for the precise removal of introns from pre-mRNA. This protein has garnered significant interest in recent years due to its critical role in RNA splicing and gene regulation, processes that are fundamental to cellular function and development. Abnormalities in splicing mechanisms have been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting the importance of PRPF40A in maintaining cellular homeostasis and the integrity of gene expression. The study of recombinant PRPF40A protein allows researchers to investigate its structure, function, and interactions with other spliceosomal components. By producing this protein in vitro, scientists can employ various biochemical and biophysical techniques to dissect its role in splicing and uncover potential regulatory pathways it may modulate. Additionally, understanding PRPF40A's contribution to splicing may open avenues for therapeutic interventions in splicing-related diseases, making it a protein of significant biomedical interest. Through these investigations, the broader implications of PRPF40A in cellular processes and its potential as a therapeutic target continue to unfold, reinforcing the need for ongoing research in this domain.
