Analytical Data
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Gene name
CASP10
- Application
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Alternative Names
CASP10；MCH4；Caspase-10
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92851
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Expression Region
220-415aa
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AA Sequence
V KTFLEALPQE SWQNKHAGSN GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEAD
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CASP10, also known as caspase-10, is a critical enzyme belonging to the caspase family, which plays a significant role in the apoptotic pathway. Apoptosis, or programmed cell death, is essential for maintaining cellular homeostasis, proper immune response, and development. Abnormal regulation of caspases, including CASP10, has been implicated in various diseases, including cancer and autoimmune disorders. The study of CASP10 is particularly relevant because mutations in the CASP10 gene have been associated with certain lymphoproliferative syndromes and contribute to the evasion of apoptosis in cancer cells, leading to tumorigenesis. Furthermore, CASP10's role in inflammation and its interaction with other apoptotic regulators highlight its potential as a therapeutic target. Research involving recombinant CASP10 protein aims to elucidate its functional mechanisms, interactions with substrates and inhibitors, and its overall contribution to apoptotic signaling pathways. By producing and characterizing recombinant CASP10, researchers can gain insights into its enzymatic activity, regulation, and potential involvement in disease processes. This understanding could pave the way for developing novel therapeutic strategies that modulate CASP10 activity, offering new avenues for treating conditions where apoptosis is dysregulated. Thus, CASP10 remains a key focus within the fields of molecular biology and medicinal research.
