Cat: PA1000-5124

Recombinant Human CASP10 Protein,His

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Analytical Data

  • 基因名

    CASP10

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CASP10;MCH4;Caspase-10

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q92851

  • 表达区间

    220-415aa

  • 氨基酸序列

    V KTFLEALPQE SWQNKHAGSN GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEAD

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

CASP10, also known as caspase-10, is a critical enzyme belonging to the caspase family, which plays a significant role in the apoptotic pathway. Apoptosis, or programmed cell death, is essential for maintaining cellular homeostasis, proper immune response, and development. Abnormal regulation of caspases, including CASP10, has been implicated in various diseases, including cancer and autoimmune disorders. The study of CASP10 is particularly relevant because mutations in the CASP10 gene have been associated with certain lymphoproliferative syndromes and contribute to the evasion of apoptosis in cancer cells, leading to tumorigenesis. Furthermore, CASP10's role in inflammation and its interaction with other apoptotic regulators highlight its potential as a therapeutic target. Research involving recombinant CASP10 protein aims to elucidate its functional mechanisms, interactions with substrates and inhibitors, and its overall contribution to apoptotic signaling pathways. By producing and characterizing recombinant CASP10, researchers can gain insights into its enzymatic activity, regulation, and potential involvement in disease processes. This understanding could pave the way for developing novel therapeutic strategies that modulate CASP10 activity, offering new avenues for treating conditions where apoptosis is dysregulated. Thus, CASP10 remains a key focus within the fields of molecular biology and medicinal research.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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