Analytical Data
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Gene name
CA5B
- Application
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Alternative Names
CA5B；Carbonic anhydrase 5B. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2D0
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Expression Region
34-317aa
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AA Sequence
CSLYTCT YKTRNRALHP LWESVDLVPG GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHVWNNGY SFLVEFEDST DKSVIKGGPL EHNYRLKQFH FHWGAIDAWG SEHTVDSKCF PAELHLVHWN AVRFENFEDA ALEENGLAVI GVFLKLGKHH KELQKLVDTL PSIKHKDALV EFGSFDPSCL MPTCPDYWTY SGSLTTPPLS ESVTWIIKKQ PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY VLNVQAKPKP ATSQATP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CA5B (carbonic anhydrase 5B) is an important enzyme belonging to the carbonic anhydrase family, which plays a critical role in maintaining acid-base balance within cells. This enzyme facilitates the reversible conversion of carbon dioxide and water into bicarbonate and protons, thus regulating intracellular pH and influencing various physiological processes, including respiration and renal function. The human CA5B gene is expressed predominantly in the brain and lungs, suggesting its involvement in neurological functions and gas exchange. Research into CA5B has gained momentum due to its potential implications in various diseases, including metabolic disorders and respiratory conditions. Furthermore, understanding its structure and function could lead to the development of novel therapeutic strategies for conditions linked to dysregulated acid-base homeostasis. Recent advances in recombinant protein technology have enabled researchers to produce CA5B in a laboratory setting, allowing for detailed studies on its enzymatic properties, interactions with inhibitors, and its role in disease mechanisms. As a result, the investigation of CA5B not only enhances our understanding of carbonic anhydrases but also paves the way for innovative approaches to targeting acid-base imbalances in clinical settings.
