Analytical Data
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基因名
PROCA1
- Application
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别名
PROCA1; Protein PROCA1; Protein interacting with cyclin A1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NCQ7
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表达区间
1-364 aa
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氨基酸序列
MWVRTTLTIE RWTKEKTEPK ARSWDESLSD VNRLPSWERG HLLAGVASST DVSTFSEGGD CKEPDKCCWR HKQCTGHIIY PFASDCVRHS LHLHSVNHCN CNSRLKDSSE DSSSSRGAGP TCSHVIESPC FELTPEEEHV ERFRYGWCKS YRPVSVAVIH HPLYHECGAD DLNEEEEEEE EESKPPIPTQ VGPATASPDL GTSMATGTPD STAPITIWRS ESPTGKGQGS KVIKKVKKKK EKEKDKEEMD EKAKLKKKAK KGQLTKKKSP VKLEPSPPDV SRSLSARQLA RMSESSPESR EELESEDSYN GRGQGELSSE DIVESSSPRK RENTVQAKKT GAKPSQARKV NKRKSPPGSN PNLS
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分子量
40.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PROCA1, a recombinant protein derived from the PROC gene, has garnered significant attention in biomedical research due to its essential role in the regulation of anticoagulation processes in the human body. The PROC gene encodes protein C, a vitamin K-dependent plasma protein that, upon activation, plays a crucial role in the coagulation cascade by inactivating factors Va and VIIIa, thereby preventing excessive blood clotting. Mutations in the PROC gene can lead to protein C deficiency, increasing the risk of thrombotic disorders, such as venous thromboembolism. Researchers have been focusing on the development of PROCA1 as a therapeutic agent, given its potential applications in treating coagulation disorders and its use as a biomarker for assessing thrombotic risk. Advances in recombinant DNA technology have facilitated the production of PROCA1 in various expression systems, enabling detailed studies on its structure, function, and interactions with other proteins in the coagulation pathway. Understanding the role of PROCA1 could lead to novel therapeutic strategies and improved management of coagulation-related diseases.
