Analytical Data
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Gene name
Pitx3
- Application
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Alternative Names
Pitx3；PTX3；Pituitary homeobox 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75364
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Expression Region
1-302aa
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AA Sequence
MEFGLLSEAE ARSPALSLSD AGTPHPQLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERSQQAELCK GSFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG GPPGLAPAAV SSGAVSCPYA SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVHGPPPAAN LSPCQYAVER PV
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Molecular Weight
31.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Pitx3, a member of the Pituitary homeobox (Pitx) gene family, plays a crucial role in the development and function of various tissues, particularly in the central nervous system and the eye. Its expression is largely confined to the midbrain, specifically in dopamine neurons, where it is essential for the survival and maintenance of these neurons. Research has shown that disruptions in Pitx3 function are implicated in neurodegenerative disorders, such as Parkinson's disease, highlighting its importance in neuronal health. Recombinant Pitx3 protein has emerged as a significant tool for studying its biological functions and molecular mechanisms. By producing and purifying this protein, researchers can investigate its roles in neuronal differentiation, gene expression regulation, and cellular signaling pathways. Moreover, understanding how Pitx3 interacts with other proteins and DNA can provide insights into its regulatory mechanisms and potential therapeutic targets. Given its involvement in neurodegeneration and developmental processes, recombinant Pitx3 protein holds promise for advancing basic biological research and developing treatments for neurodegenerative diseases, fostering a greater understanding of its role in neuronal health and disease pathology.
